Immunoglobulin preparations

Biotest’s immunoglobulin preparations are ready-made solutions for infusion.
Their immunoglobulin preparations are safe to use because of:

1. Pentaglobin® For the pre-term neonate or new born
The chance to survive sepsis

The Hyperimmunoglobulin with IgM, restoring natural immunity
Pentaglobin® contains all the important classes of immunoglobulin circulating in the blood: IgG, IgA and IgM. IgM accelerates the phagocytosis of bacterial and viral antigens. It neutralises toxins and autoantibodies, activates and regulates the complement system.

Pentaglobin® 28 / 30.2 / 0007 -10 ml Ampoule
Pentaglobin® 28 / 30.2 / 0008 - 20 ml Ampoule
Pentaglobin® 28 / 30.2 / 0009 - infusion bottles 50 ml & 100 ml

1. Intraglobin F® Treatment of autoimmune diseases, safe and effective

Normal Human Immunoglobulin for intravenous use
Intraglobin F®, functionally intact and well tolerated, contains the antibody spectrum of the normal population in a 5-fold higher concentration.

Intraglobin® F 28 / 30.2 / 0800 – 10 ml Ampoule
Intraglobin® F 28 / 30.2 / 0107 – 20 ml Ampoule
Intraglobin® F 28 / 30.2 / 0061 – infusion bottles 50 ml, 100 ml and 200 ml

Plasma Expander and Plasma Substitute

Haemaccel

Indications:

Contra indications:
History of anaphylactic reactions

Special precautions in cases such as :
Increased stroke volume , elevated blood pressure, where there is increased interstitial fluid conditions like congestive hart failure , hypertension, pulmonary oedema.
Patients with an increased risk if histamine release, or patients who had received a drug which releases histamine during the previous 7 days.
Preserved blood should not be mixed with Haemaccel.

Dosage:
Rate of infusion is controlled by monitoring the blood pressure .
Drop count can be controlled from the following formula;-
Intended amount of infusion in ml divided by 4 x intended infusion time in hours.
Example: 500 ml =125 drops per minute
4 x1 hour
In emergencies , where immediate volume replacement is indicated infusion can be done rapidly (e.g. 500ml in 5-15 minutes)
Reactions caused by histamine release can be reduced by prophylactic use of H1 and H2 receptor antagonists (e.g. CImetidine -10mg/kg i.v.).

Adults:
Loss of blood or plasma.
Shock prophylaxis 500ml 1500ml
Volume deficiency shock max 2000ml
Blood pressure is the parameter of reference. Haemaccel may be mixed with saline , glucose, ringers solutions, corticosteroids , muscle relaxants, barbiturates, , vitamins, streptokinase and antibiotics of the penicillin series –provided they are water soluble

Side effects:
Transient skin reactions, tachycardia, bradycardici, nausea, vomiting - hypotension